THERAPEUTIC APPLICATIONS OF QUADRUPLEX NUCLEID ACIDS

Description New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research. Author Info By Stephen Neidle, The School of Pharmacy, University of London, UK Therapeutic Applications of Quadruplex Nucleic Acids, 1st Edition Intro - history and milestones Fundamentals of DNA and RNA quadruplex structure and stability Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit Quadruplex ligands - chemistry and design - selectivity and assays Quadruplex ligands - basic biology and assays indirect and direct Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding Future directions and conclusions