INDUSTRIALIZATION OF DRUG DISCOVERY

The pharmaceutical industry suffers from an innovation deficit, with clinical attrition and safety-related market-withdrawal rates at the same level as twenty years ago. This book scrutinizes this problem in detail, contrasting the promise of technology and industrialization with the apparent inability of industry to fully realize the tools that are available. The text begins by introducing the evolution of modern drug discovery, tracing it from basic concepts to current approaches. The editor devotes the remainder of the discussion to the regulatory environment, industrialization, compound and knowledge management functions, the drug screening process, collaboration, and finally, ethical issues.