STEFANIE D. KRAMER

Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations.The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry.The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials.Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrates classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties.

Todos conocemos a Kramer: el comediante, el triunfador del Festival de Viña del Mar, el imitador que sorprende y hace reír en el cine, la televisión, los shows en vivo y en los medios digitales desde hace 20 años.Pero, muy pocos conocen a Stefan.En estas memorias breves, por primera vez, el artista de las mil caras que siempre ha evitado mostrarse, autoriza al hombre que le da vida a revelar, sin maquillaje, quien es, como hace lo que hace, que ideas y sueños lo movilizan.Con veloces anecdotas, dialogos hilarantes y reflexiones de profunda ternura y emocion, Stefan Kramer arma un inspirador relato que recorre sus busquedas vitales, desde los momentos mas bajos y perplejos, hasta los mas luminosos, absurdos y chistosos.Esta no es mi biografia, porque recien tengo 40 años. Pero quizas este relato te inspire, te motive o te haga reir. Y eso es muy bueno, porque a todos nos hace tanta falta reir, dice el autor.Y cierra su libro con un anuncio: Kramer esta listo para el proximo paso.